Gene–Environment Interaction: A Variable Selection Perspective

Gene–environment interactions have important implications for elucidating the genetic basis of complex diseases beyond joint function multiple factors and their (or epistasis). In past, G × E been mainly conducted within framework association studies. The high dimensionality interactions, due to complicated form environmental effects presence a large number including gene expressions SNPs, has motivated recent development penalized variable selection methods dissecting which ignored in majority published reviews on interaction this article, we first survey existing studies both gene–environment gene–gene interactions. Then, after brief introduction methods, review penalization relevant marginal paradigms, respectively, under variety conceptual models. Discussions strengths limitations, as well computational aspects tailored studies, also provided.